IU1 - Wikipedia Bahasa Melayu, ensiklopedia bebas

IU1
Pengecam
	Nama IUPAC 1-[1-(4-fluorofenil)-2,5-dimetilpirol-3-il]-2-pirolidin-1-iletanona;
Nombor CAS	314245-33-5;
PubChem CID	675434;
ChEBI	CHEBI:232499;
ChEMBL	ChEMBL1410015;
CompTox Dashboard (EPA)	DTXSID80350196 ;
Data kimia dan fizikal
Formula	C18H21FN2O
Jisim molar	300.38 g·mol−1
Model 3D (JSmol)	Gambar interaktif;
	SMILES CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3;
	InChI InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3; Key:JUWDSDKJBMFLHE-UHFFFAOYSA-N;

IU1 ialah sejenis ubat yang digunakan dalam penyelidikan saintifik yang bertindak sebagai perencat terpilih enzim protease pemprosesan khusus ubiquitin USP14.^[1] Ia menarik perhatian dalam penyelidikan anti-kanser dan antivirus, serta berpotensi dijadikan sebagai ubat anti-penuaan. Banyak derivatif IU1 telah dibangunkan dengan sehingga mencapai 10x potensi berbanding IU1 sebagai perencat USP14,^[2]^[3] tetapi IU1 kekal berperanan sebagai sebatian yang paling banyak digunakan dalam penyelidikan dalam bidang-bidang berkaitan.^[4]^[5]^[6]^[7]^[8]^[9]^[10]

Rujukan

^ "Enhancement of proteasome activity by a small-molecule inhibitor of USP14". Nature. 467 (7312): 179–84. September 2010. Bibcode:2010Natur.467..179L. doi:10.1038/nature09299. PMC 2939003. PMID 20829789.
^ "Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade". Cell Research. 28 (12): 1186–1194. December 2018. doi:10.1038/s41422-018-0091-x. PMC 6274642. PMID 30254335.
^ "An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons". The Journal of Biological Chemistry. 292 (47): 19209–19225. November 2017. doi:10.1074/jbc.M117.815126. PMC 5702663. PMID 28972160.
^ "A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication". Virus Research. 165 (1): 103–106. April 2012. doi:10.1016/j.virusres.2012.01.009. PMID 22306365.
^ "Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases". International Journal of Molecular Sciences. 22 (12): 6213. June 2021. doi:10.3390/ijms22126213. PMC 8226605. PMID 34207520.
^ "USP14: Structure, Function, and Target Inhibition". Frontiers in Pharmacology. 12. 2022. doi:10.3389/fphar.2021.801328. PMC 8766727 Check |pmc= value (bantuan). PMID 35069211 Check |pmid= value (bantuan).
^ "Inhibition of USP14 Suppresses ROS-dependent Ferroptosis and Alleviates Renal Ischemia/Reperfusion Injury". Cell Biochemistry and Biophysics. 81 (1): 87–96. March 2023. doi:10.1007/s12013-022-01107-y. PMID 36255562 Check |pmid= value (bantuan).
^ "USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice". CNS Neuroscience & Therapeutics. 29 (11): 3612–3623. November 2023. doi:10.1111/cns.14292. PMC 10580339 Check |pmc= value (bantuan). PMID 37269080 Check |pmid= value (bantuan).
^ "Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner". Autophagy. 20 (12): 2752–2768. December 2024. doi:10.1080/15548627.2024.2389607. PMC 11587835 Check |pmc= value (bantuan). PMID 39113571 Check |pmid= value (bantuan).
^ "USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5". Theranostics. 15 (6): 2293–2314. 2025. doi:10.7150/thno.103629. PMC 11840735 Check |pmc= value (bantuan). PMID 39990235 Check |pmid= value (bantuan).

[Lee_2010-1] "Enhancement of proteasome activity by a small-molecule inhibitor of USP14". Nature. 467 (7312): 179–84. September 2010. Bibcode:2010Natur.467..179L. doi:10.1038/nature09299. PMC 2939003. PMID 20829789.

[Wang_2018-2] "Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade". Cell Research. 28 (12): 1186–1194. December 2018. doi:10.1038/s41422-018-0091-x. PMC 6274642. PMID 30254335.

[Boselli_2017-3] "An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons". The Journal of Biological Chemistry. 292 (47): 19209–19225. November 2017. doi:10.1074/jbc.M117.815126. PMC 5702663. PMID 28972160.

[4] "A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication". Virus Research. 165 (1): 103–106. April 2012. doi:10.1016/j.virusres.2012.01.009. PMID 22306365.

[5] "Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases". International Journal of Molecular Sciences. 22 (12): 6213. June 2021. doi:10.3390/ijms22126213. PMC 8226605. PMID 34207520.

[6] "USP14: Structure, Function, and Target Inhibition". Frontiers in Pharmacology. 12. 2022. doi:10.3389/fphar.2021.801328. PMC 8766727 Check |pmc= value (bantuan). PMID 35069211 Check |pmid= value (bantuan).

[7] "Inhibition of USP14 Suppresses ROS-dependent Ferroptosis and Alleviates Renal Ischemia/Reperfusion Injury". Cell Biochemistry and Biophysics. 81 (1): 87–96. March 2023. doi:10.1007/s12013-022-01107-y. PMID 36255562 Check |pmid= value (bantuan).

[8] "USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice". CNS Neuroscience & Therapeutics. 29 (11): 3612–3623. November 2023. doi:10.1111/cns.14292. PMC 10580339 Check |pmc= value (bantuan). PMID 37269080 Check |pmid= value (bantuan).

[9] "Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner". Autophagy. 20 (12): 2752–2768. December 2024. doi:10.1080/15548627.2024.2389607. PMC 11587835 Check |pmc= value (bantuan). PMID 39113571 Check |pmid= value (bantuan).

[10] "USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5". Theranostics. 15 (6): 2293–2314. 2025. doi:10.7150/thno.103629. PMC 11840735 Check |pmc= value (bantuan). PMID 39990235 Check |pmid= value (bantuan).

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Pengecam

Nama IUPAC 1-[1-(4-fluorofenil)-2,5-dimetilpirol-3-il]-2-pirolidin-1-iletanona
Nombor CAS	314245-33-5
PubChem CID	675434
ChEBI	CHEBI:232499
ChEMBL	ChEMBL1410015
CompTox Dashboard (EPA)	DTXSID80350196
Data kimia dan fizikal
Formula	C₁₈H₂₁FN₂O
Jisim molar	300.38 g·mol⁻¹
Model 3D (JSmol)	Gambar interaktif
SMILES CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
InChI InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3 Key:JUWDSDKJBMFLHE-UHFFFAOYSA-N